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KMID : 0352519940310030325
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Korea Univercity Medical Journal
1994 Volume.31 No. 3 p.325 ~ p.336
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The Ventral Medulla Involved in APT-induced Antinociception in Rats
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Abstract
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Analgesia resulting from stimulation of brain(stimulation-produced analgesia)has been extensively studied.
It has been shown that the anterior pretectal nucleus(APT) is involved in somatosensory motor integration, although the pretectal complex is traditionally known to be involved in visual information processing. Stimulation of the APT
inhibits tail-flick and jaw-opening reflexes and produces antinociception. But descending modulatory circutis involved in the antinociceptive effects of APT stimulation are not clear.
Mate Spraue Dawley rats were subjected as experimontal animals. Each rat was anesthetized with mixture of α-chloralose and urethane and placed in a stereotacxic frame.
The jaw-opening reflex(JOR)which was elicited by electrical stimulation of the upper lip was monitored by recording the evoked digastric muscle activity.
Electrolytic lesions of the ventral medulla(VM)at the level of the inferior olivary nuclei(IO) or microinjections of lidocaine into the VM significantly reduced the APT-induced inhibition of the JOR. Electrical stimulation of the VM at the
level of
the IO or microinjection of glutamate into the VM significantly inhibited the JOR.
These findings suggest that the inhibitory effects of APT stimulation on the JOR were mediated in part by a relay station in the VM at the level of the IO.
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